p-Toluenesulfonic acid monohydrate → HCID 178487532, compound

Participants

Reaction Steps

A mixture of 1.0 gram of N2 -(7-methoxy-2-naphthalenesulfonyl)-L-arginine, 1.0 gram of p-toluenesulfonic acid monohydrate in 5 ml of benzyl alcohol and 30 ml of benzene was refluxed for 5 hours, removing water by azeotropic distillation. After the solvent was removed by distillation, 100 ml of ethyl ether was added to the residae, giving a crystalline mass of N2 -(7-methoxy-2-naphthalenesulfonyl)-L-arginine benzyl ester p-toluenesulfonate in 94% yield; mp. 115 - 117° C.

Provenance & Evidence