HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzene → 2-(Bromomethyl)-2-(4-chlorophenyl)-4-phenyl-1,3-dioxolane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzene | HCID 241 | — |
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | 1-Phenyl-1,2-ethanediol | HCID 7149 | — |
| Reactant | p-Chlorophenacyl bromide | HCID 68303 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-(Bromomethyl)-2-(4-chlorophenyl)-4-phenyl-1,3-dioxolane | HCID 20332635 | — |
Reaction Steps
A mixture of 11.6 parts of 2-bromo-4'-chloroacetophenone, 8.4 parts of α-(hydroxymethyl)benzylalcohol, 0.1 parts of p-toluene sulfonic acid, 210 parts of benzene and 40 parts of ethanol is stirred and refluxed for 24 hours. The reaction mixture is evaporated and the residue is triturated in methanol. The product is filtered off and crystallized from methanol, yielding 2-(bromomethyl)-2-(p-chlorophenyl)-4-phenyl-1,3-dioxolane; mp. 60° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04139540 |
| Source dataset | uspto-grants-1979_02 |
| ORD ID | ord-edba95a548744c0a8ea44fb6c6630634 |
| Source note | uspto-grants-1979_02 |