Acetic Anhydride → HCID 21333182, compound

HRID 1390619Notes

Reaction equation

HRID 1390619 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([N:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)[CH:5]=[C:6]([Cl:9])[C:7]=1[Cl:8].[C:16](OC(=O)C)(=[O:18])[CH3:17]>C(O)C>[C:16]([N:13]1[CH2:12][CH2:11][N:10]([C:4]2[CH:3]=[C:2]([Cl:1])[C:7]([Cl:8])=[C:6]([Cl:9])[CH:5]=2)[CH2:15][CH2:14]1)(=[O:18])[CH3:17]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 21333175HCID 21333175, compound

Product 1

HCID 21333182HCID 21333182, compoundYield 76%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 1-(3,4,5-trichlorophenyl) piperazine (0.5 g) and acetic anhydride (0.4 ml) in ethanol (10 ml) was left to stand overnight at ambient temperature. The solvent was removed in vacuo and the residue was crystallised from ethyl acetate-light petroleum (b.p. 40°-60°) to give 1-acetyl-4-(3,4,5-trichlorophenyl) piperazine (0.43g, 76%), m.p. 133°-136°.

Workup

  1. waitwas left
  2. customThe solvent was removed in vacuo
  3. customthe residue was crystallised from ethyl acetate-light petroleum (b.p. 40°-60°)

Sources & evidence

ORD record
ord-cd89c635f40742e1a010bf7d6032dc76
Source dataset
uspto-grants-1979_02
Patent number
US04139621

Reaction notes

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