Potassium Bicarbonate → HCID 70605278, compound

Participants

Reaction Steps

To a solution of 5-androstene-3β,17β,19-triol 3,19-diacetate in methanol is added one equivalent of an aqueous 2% solution of potassium bicarbonate. The mixture is heated at its reflux temperature for a period of about 2 hours, concentrated to a small volume under reduced pressure and ether added thereto. The ethereal solution is separated, washed with water, dried over magnesium sulfate and evaporated in vacuo. The residue so obtained is crystallized from an acetone-hexane solution to furnish the desired 5-androstene-3β,17β,19-triol 19-acetate.

Provenance & Evidence