Potassium sodium tartarate → 1beta-Methyl-5-androstene-3beta,17beta,19-triol

Participants

Reaction Steps

A tetrahydrofuran solution of 19-hydroxy-1β-methyl-5-androstene-3,17-dione is added under nitrogen to a solution of lithium tri-t-butoxyaluminum hydride in tetrahydrofuran. After stirring at room temperature for about 18 hours, an aqueous solution of potassium sodium tartrate is added with stirring to form a readily filterable white solid. The reaction mixture is filtered, the filtrate dried over magnesium sulfate, and the solvent removed. The residue which remains is crystallized from an acetone-hexane solution to yield 1β-methyl-5-androstene-3β,17β,19-triol.

Provenance & Evidence