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HRID1390750

反应详情

EQUATION

反应方程式

HRID 1390750 的结构方程式

REACTANTS

反应物

1
结构：C[C@@H]1CC2=C[C@@H](O)CC[C@]2(CO)[C@H]2CC[C@]3(C)[C@@H](O)CC[C@H]3[C@H]12
HCID70584982

未命名化合物

PRODUCTS

生成物

1
结构：C[C@@H]1CC2=CC(=O)CC[C@]2(CO)[C@H]2CC[C@]3(C)[C@@H](O)CC[C@H]3[C@H]12
HCID70584995

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：[Mn+4].[O-2].[O-2]
催化剂HCID178418406

未命名化合物

结构：ClC(Cl)Cl
溶剂HCID6212

Chloroform

CHCl3

CONDITIONS

反应条件

温度
15 °C

PROCEDURE

实验过程

7α-Methyl-4-androstene-3β,17β,19-triol is dissolved in hot chloroform and cooled to 15° C. Activated manganese dioxide is added at a rate such that the temperature does not rise above 25° C. Stirring is continued at room temperature for about 1 hour, the manganese dioxide is removed by filtration through a bed of diatomaceous earth and the chloroform distilled under vacuum. The residue which remains is crystallized from acetonitrile to yield 17β,19-dihydroxy-7α-methyl-4-androsten-3-one.

WORKUP

后处理

  1. customdoes not rise above 25° C
  2. customthe manganese dioxide is removed by filtration through a bed of diatomaceous earth
  3. distillationthe chloroform distilled under vacuum
  4. customThe residue which remains is crystallized from acetonitrile