HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 19-Methoxyandrost-4-ene-3,17-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 19-Hydroxyandrostenedione | HCID 252379 | — |
| Reactant | Oxonium, trimethyl-, tetrafluoroborate(1-) (1:1) | HCID 2735153 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 19-Methoxyandrost-4-ene-3,17-dione | HCID 54153042 | — |
Reaction Steps
19-Hydroxyandrost-4-ene-3,17-dione is dissolved in methylenechloride and trimethyloxonium fluoroborate added thereto. After stirring at room temperature for a period of two hours, water is added to the reaction mixture, the organic layer is separated, dried over magnesium sulfate and the solvent removed under vacuum. The residue is crystallized from an acetone-hexane solution to yield the desired 19-methoxyandrost-4-ene-3,17-dione.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04139617 |
| Source dataset | uspto-grants-1979_02 |
| ORD ID | ord-988be6b66f074c808c733a419c54a46e |
| Source note | uspto-grants-1979_02 |