19-t-Butyldimethylsiloxy-4-androstene-3,17-dione → 19-t-Butyldimethylsiloxy-6-methyl-5-androstene-3,17-dione

Participants

Reaction Steps

Substituting 19-t-butyldimethylsiloxy-6α-methyl-4-androstene-3,17-dione, 19-(4'-tetrahydropyranyloxy)androst-4-ene-3,17-dione, 4-methyl-17β,19-di(4'-tetrahydropyranyloxy)-4-androsten-3-one and 1β-methyl-19-(4'-tetrahydropyranyloxy)-4-androsten-3,17-dione for the 19-t-butyldimethylsiloxy-4-androstene-3,17-dione above results in the preparation of 19-t-butyldimethylsiloxy-6-methyl-5-androstene-3,17-dione, 19-(4'-tetrahydropyranyloxy)androst-5-ene-3,17-dione, 4α-methyl-17β,19-di(4'-tetrahydropyranyloxy)-5-androsten-3-one and 1β-methyl-19-(4'-tetrahydropyranyloxy)-5-androsten-3,17dione, respectively.

Provenance & Evidence