HuagongsheHuagongshe Chemistry Print Report · For research reference only
17beta,19-Dihydroxy-5-androsten-3-one → 19-t-Butyldimethylsiloxy-5-androstene-3alpha,17-diol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 17beta,19-Dihydroxy-5-androsten-3-one | HCID 11748732 | — |
| Reactant | 19-t-Butyldimethylsiloxy-5-androstene-3,17-dione | HCID 70605354 | — |
| Product | 19-t-Butyldimethylsiloxy-5-androstene-3alpha,17-diol | HCID 70605735 | — |
Reaction Steps
Substituting 19-t-butyldimethylsiloxy-5-androstene-3,17-dione, 4α-methyl-17β,19-di(4'-tetrahydropyranyloxy)-5-androsten-3-one and 1β-methyl-19-(4'-tetrahydropyranyloxy)-5-androstene-3,17-dione for the 17β,19-dihydroxy-5-androsten-3-one above results in the preparation of 19-t-butyldimethylsiloxy-5-androstene-3α,17-diol, 4α-methyl-17β,19-di(4'-tetrahydropyranyloxy)-5-androsten-3α-ol and 1β-methyl-19-(4'-tetrahydropyranyloxy)-5-androstene-3α,17β-diol, respectively.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04139617 |
| Source dataset | uspto-grants-1979_02 |
| ORD ID | ord-86950ed2e3264be7af1ea97fded63bfb |
| Source note | uspto-grants-1979_02 |