Ammonium Chloride → 19-Trimethylsiloxy-5-androstene-3,17-dione

Participants

Reaction Steps

To a solution of potassium t-butoxide in dimethylsulfoxide at 25° C. under nitrogen is added a solution of 19-trimethylsiloxy-4-androstene-3,17-dione in dimethylsulfoxide with stirring. After 15 minutes the mixture is poured onto a cold aqueous ammonium chloride solution. The solid so obtained is rapidly filtered, washed well with water and dissolved in ether. The ether solution is washed well with water, dried over sodium sulfate and the ether removed at room temperature to yield 19-trimethylsiloxy-5-androstene-3,17-dione.

Provenance & Evidence