Sodium Carbonate → HCID 86736334, compound

HRID 1390793Notes

Reaction equation

HRID 1390793 reaction equation
C(O)(=O)C.[CH2:5]([O:7][C@H:8]1[CH2:25][CH2:24][C@@:23]2([CH:26]=[O:27])[C:10](=[CH:11][CH2:12][C@@H:13]3[C@@H:22]2[CH2:21][CH2:20][C@@:18]2([CH3:19])[C@H:14]3[CH2:15][CH2:16][C@@H:17]2[OH:28])[CH2:9]1)[CH3:6].C(=O)([O-])[O-].[Na+].[Na+]>CO>[CH2:5]([O:7][C@H:8]1[CH2:25][CH2:24][C@@:23]2([CH:26]=[O:27])[C:10](=[CH:11][CH2:12][C@@H:13]3[C@@H:22]2[CH2:21][CH2:20][C@@:18]2([CH3:19])[C@H:14]3[CH2:15][CH2:16][C@@H:17]2[OH:28])[CH2:9]1)[CH3:6]

Participants

4

Reactant 2

HCID 10340Sodium CarbonateHCID 86736333HCID 86736333, compound

Product 1

HCID 86736334HCID 86736334, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 3β-ethoxy-17β-hydroxy-5-androsten-19-one acetate and sodium carbonate in 10% aqueous methanol is refluxed for a period of about four hours. The cooled solution is poured onto water. The crystals which form are filtered and recrystallized from an acetone-water mixture to yield 3β-ethoxy-17β-hydroxy-5-androsten-19-one.

Workup

  1. additionThe cooled solution is poured onto water
  2. filtrationThe crystals which form are filtered
  3. customrecrystallized from an acetone-water mixture

Sources & evidence

ORD record
ord-4c9dd9c684ec4019950e7bc547e7c014
Source dataset
uspto-grants-1979_02
Patent number
US04139617

Reaction notes

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