HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 2-[5-(4-Chlorophenyl)-1,2-oxazol-3-yl]benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 12789648 | HCID 12789648 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-[5-(4-Chlorophenyl)-1,2-oxazol-3-yl]benzoic acid | HCID 12392115 | 95.3% |
Reaction Steps
A mixture of 2.8 g of methyl 2-[5-(4-chlorophenyl)3-isoxazolyl]benzoate, 12 ml of concentrated HCl, and 14 ml of acetic acid was held at reflux for 4 hours, cooled, diluted with water, and filtered to give 2.55 g (95%) of white solid, mp 174-176° C. Recrystallization of the solid gave 2.18 g of solid, mp 175.5-177.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04140515 |
| Source dataset | uspto-grants-1979_02 |
| ORD ID | ord-76e74cc7dfa846dba12be70f289f2032 |
| Source note | uspto-grants-1979_02 |