Sodium Hydroxide → HCID 178514626, compound

Participants

Reaction Steps

A solution of 4.8 g of N2 -(2-phenoxathiinylsulfonyl)-L-arginyl-N-tetrahydrofurfurylglycine ethyl ester in 15 ml of methanol and 15 ml of 2N-NaOH solution was warmed to 40° C. and held at that temperature for 10 hours. At the end of this period, the reaction mixture was concentrated and chromatographed on 200 ml of Daiaion® SK 102 ion exchange resin (200-300 mesh, H+ form, manufactured by Mitsubishi Chemical Industries Limited) packed in water, washed with ethanol-water (1:4) and eluted with ethanol-water-NH4OH (10 : 9 : 1). The main fraction was evaporated to dryness and washed with ethyl ether to give 3.2 g (80 percent) of N2 -(2-phenoxathiinylsulfonyl)-L-arginyl-N-tetrahydrofurfurylglycine as an amorphous solid. I.R. (KBr): 3350, 1640, 1250 cm-1

Provenance & Evidence