HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → Codeinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | Carbon Dioxide | HCID 280 | — |
| Reactant | Thebaine | HCID 5324289 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | Codeinone | HCID 5459910 | — |
Reaction Steps
Anhydrous hydrogen bromide in glacial acetic acid (6 ml of 45% w/v solution) was added dropwise with stirring to a cooled (-15° C.) solution of thebaine (2 g) in chloroform (6 ml) over a period of 9 minutes. When the addition was complete the Drikold bath was removed and the temperature allowed to rise.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04140687 |
| Source dataset | uspto-grants-1979_02 |
| ORD ID | ord-91379730c94043939784645b16d71596 |
| Source note | uspto-grants-1979_02 |