1-Chloro-4-(chloromethyl)benzene → HCID 12789007, compound

HRID 1390827Notes

Reaction equation

HRID 1390827 reaction equation
[C:1]([C:4]1[C:5]([N:16]=[CH:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[C:6]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[NH:7][C:8]=1[CH3:9])(=[O:3])[CH3:2].[Cl:24][C:25]1[CH:32]=[CH:31][C:28]([CH2:29]Cl)=[CH:27][CH:26]=1>C(O)C.O>[C:1]([C:4]1[C:5]([N:16]=[CH:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[C:6]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[N:7]([CH2:29][C:28]2[CH:31]=[CH:32][C:25]([Cl:24])=[CH:26][CH:27]=2)[C:8]=1[CH3:9])(=[O:3])[CH3:2].[C:1]([C:4]1[C:5]([NH2:16])=[C:6]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[N:7]([CH2:29][C:28]2[CH:31]=[CH:32][C:25]([Cl:24])=[CH:26][CH:27]=2)[C:8]=1[CH3:9])(=[O:3])[CH3:2]

Participants

5

Reactant 2

HCID 77231-Chloro-4-(chloromethyl)benzeneHCID 12789002HCID 12789002, compound

Product 2

HCID 12789007HCID 12789007, compoundHCID 20330051HCID 20330051, compound

Reagents, catalysts & solvents 1

HCID 19096565Water ethanolSolvent2×

Procedure

The 4-acetyl-3-benzylideneamino-1-(p-chlorobenzyl)-5-methyl-2-phenylpyrrole is prepared from the compound of Example 46 and p-chlorobenzyl chloride by procedure (a) of Example 49, m.p. 136°-37° C. (from ethanol/water). This compound is hydrolyzed as in procedure (b) of Example 49. Yield of the title compound: 58%, m.p. 164°-66° C. (from ethanol/water).

Sources & evidence

ORD record
ord-ea30d3ca797b464da716fe5f4c8c954d
Source dataset
uspto-grants-1979_02
Patent number
US04140696

Reaction notes

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