Benzyl acetone → HCID 12952453, compound

HRID 1390914Notes

Reaction equation

HRID 1390914 reaction equation
[F:1]C1C=CC(C(=O)CN(CC2C=CC=CC=2)CC2C=CC=CC=2)=CC=1S(N)(=O)=O.C1(CCC(=O)C)C=CC=CC=1.[ClH:41].[F:42][C:43]1[CH:48]=[CH:47][C:46]([CH:49]([OH:62])[CH2:50][NH:51][CH:52]([CH3:61])[CH2:53][CH2:54][C:55]2[CH:60]=[CH:59][CH:58]=[CH:57][CH:56]=2)=[CH:45][C:44]=1[S:63]([NH2:66])(=[O:65])=[O:64]>>[ClH:41].[F:42][C:43]1[CH:48]=[CH:47][C:46]([CH:49]([OH:62])[CH2:50][NH:51][CH:52]([CH3:61])[CH2:53][CH2:54][C:55]2[CH:60]=[CH:59][C:58]([F:1])=[CH:57][CH:56]=2)=[CH:45][C:44]=1[S:63]([NH2:66])(=[O:65])=[O:64]

Participants

4

Reactant 3

HCID 17355Benzyl acetoneHCID 12952410HCID 12952410, compoundHCID 12952431HCID 12952431, compound

Product 1

HCID 12952453HCID 12952453, compound

Procedure

In a similar manner 2-fluoro-5-[[bis(phenylmethyl)amino] acetyl]-benzenesulphonamide (2.5 g) and 4-phenyl-butan-2-one (5 g) were converted into 2-fluoro-5-[1-hydroxy-2-[(1-methyl-3-phenylpropyl)amino]ethyl]benzenesulphonamide, hydrochloride, 0.4 g, m.p. BO°-95°.

Workup

  1. customm.p. BO°-95°

Sources & evidence

ORD record
ord-875fd5fd95d846179295e92ecc0d5c45
Source dataset
uspto-grants-1979_02
Patent number
US04140713

Reaction notes

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