Potassium Hydroxide → HCID 21331692, compound

Participants

Reaction Conditions

Reaction Steps

102.9 g (0.9 mole) of methanesulfonic acid chloride were added dropwise at 0° C. to a solution of 100.8 g (0.9 mole) of 1,6-dihydroxypyridazine and 50.4 g (0.9 mole) of potassium hydroxide in 500 ml of water. The mixture was allowed to react for a further hour at 20° C. and was then cooled to -10° C., and the precipitate formed was filtered off. After recrystallization from acetonitrile, 87 g (51% of theory) of 1,6-dihydro-3-methylsulfonyloxy-6-oxopyridazine were obtained in the form of colorless crystals of melting point 148° C. ##STR194##

Provenance & Evidence