Potassium Carbonate → HCID 70604238, compound

Participants

Reaction Steps

Fifteen grams of the propiophenone derivative are dissolved in 100 ml water-free acetone. Twenty-four grams (200% excess) potash are added while stirring well. Subsequently, 24.0 grams (200% excess) diethylaminoethylchloride, dissolved in 100 ml acetone, are added dropwise. After having boiled it under reflux for 1 day, the precipitate is filtered off, the acetone evaporated and the residue taken up with dry ether. After having precipitated the hydrochloride and sucked off the residue, several recrystallizations from methanol/ether are effected. Ten grams [43.3%] 4-[2-(N,N-diethylamino)-ethoxy]-3,5-dimethyl-β-phenylpropiophenone hydrochloride (melting point of 128° C.) are obtained.

Provenance & Evidence