Water → HCID 20088731, compound

Participants

Reaction Steps

Five grams of the butyrophenone are dissolved in 100 mls of methyl ethyl ketone; 4.2 grams of water-free potash are added to this. The reaction medium is well stirred while adding dropwise 5.2 grams of diethylaminoethylchloride. This mixture is boiled under reflux for 3 days. The inorganic salts are sucked off, the methyl ethyl ketone is evaporated in vacuo, and, after taking up the residue in ether, it is washed several times with water. After drying the ethereal phase with sodium sulfate, the hydrochloride is precipitated by adding ethereal hydrochloric acid. 4-[2-N,N-diethylamino)-ethoxy]-3,5-dimethyl-γ-[4'-chloro-3'-methyl)-phenoxy]-butyrophenone hydrochloride (Melting point of 156° C.), is obtained.

Provenance & Evidence