Water → HCID 54122965, compound

Participants

Reaction Steps

Fifty grams (0.15 mol) of 4-hydroxy-3,5-dimethyl-β,β-diphenylpropiophenone (prepared as in Example 5), dissolved in 200 mls of acetone, are added, with stirring, to a reaction mixture consisting of 29 grams (0.184 mol) of 1-bromo-3-chloropropane in 300 mls of acetone and 42 grams (0.304 mol) of water-free potash. The preparation is boiled under reflux for one day and the precipitate is sucked off. The acetone is evaporated, the residue taken up with ether and a little acetone and, subsequently, washed with water. The ethereal phase is dried over sodium sulfate. The solvent is evaporated in vacuo. The residue is crystallized from acetone/petroleum ether. Fifty-two and five-tenths grams [85.5%] of 4-(3-bromopropoxy)-3,5-dimethyl-β,β-diphenylpropiophenone are obtained.

Provenance & Evidence