2,5-Dimethylphenol → HCID 54001442, compound

HRID 1390942Notes

Reaction equation

HRID 1390942 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([OH:9])[C:5](C)=[CH:6][CH:7]=1.[Cl-].[Al+3].[Cl-].[Cl-].Cl[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>C1(C(C2C=CC=CC=2)CC(Cl)=O)C=CC=CC=1>[OH:9][C:4]1[CH:3]=[C:2]([CH3:1])[C:7]([C:2]([CH3:1])([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH2:3][C:4]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[O:9])=[CH:6][CH:5]=1

Participants

5

Reactant 3

HCID 72672,5-DimethylphenolHCID 7964Chlorobenzene2×HCID 6451240Aluminum(III) Chloride

Product 1

HCID 54001442HCID 54001442, compound

Reagents, catalysts & solvents 1

HCID 30158933,3-Diphenylpropionyl chlorideSolvent

Procedure

Twenty-four and four-tenths grams of 3,6-dimethylphenol and 26.6 grams of aluminum chloride are dissolved in 250 mls chlorobenzene and 48.9 grams of 3,3-diphenylpropionic acid chloride, dissolved in 150 mls chlorobenzene, are added while stirring. The stirring is continued for several days at 100° C. The chlorobenzene is evaporated in vacuo, the residue is mixed with ice and ether and washed several times with water. After drying with sodium sulfate, the ether is evaporated. Fifteen and one-tenth grams of 4-hydroxy-3,6-dimethyl-β,β-diphenylpropiophenone are obtained.

Workup

  1. additionare added
  2. waitThe stirring is continued for several days at 100° C
  3. customThe chlorobenzene is evaporated in vacuo
  4. additionthe residue is mixed with ice and ether
  5. washwashed several times with water
  6. dry with materialAfter drying with sodium sulfate
  7. customthe ether is evaporated

Sources & evidence

ORD record
ord-35cc30991c614dca835ae308f304e07d
Source dataset
uspto-grants-1979_02
Patent number
US04140770

Reaction notes

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