3-(4-Chlorophenyl)-4,5-dihydro-1H-pyrazole → 1-[(3-Chloro-4-monochlorodifluoromethoxy-phenyl)-carbamoyl]-3-(4-chlorophenyl)-2-pyrazoline

Participants

Reaction Conditions

Reaction Steps

12.7 g (0.05 mol) of 3-chloro-4-monochlorodifluoromethoxy-phenyl isocyanate in 20 ml of toluene were added, at 60° C., to a solution of 9 g (0.05 mol) of 3-(4-chlorophenyl)-2-pyrazoline in 60 ml of toluene. The batch was stirred for 2 hours at 80° C. On cooling to room temperature, the product precipitated and was filtered off. 8.5 g (39% of theory) of 1-[(3-chloro-4-monochlorodifluoromethoxy-phenyl)-carbamoyl]-3-(4-chlorophenyl)-2-pyrazoline with a melting point of 161° C. were obtained.

Provenance & Evidence