HCID 791403, compound → HCID 21331819, compound

Participants

Reaction Steps

To a suspension of 4-(o-tolyl)-1-(p-nitrobenzyl)piperazine (3.11 g, 0.01 M) in 30 ml of ether is added dropwise 30 ml of titanium trichloride (20% aqueous solution). The resulting mixture is stirred at room temperature for one hour. This is then quenched into cold water, made strongly basic with aqueous 10% ammonium hydroxide solution and extracted with methylene chloride. The methylene chloride solution is washed with water, dried over anhydrous sodium sulfate and concentrated to an oil. This is purified by column chromatography on silica gel to afford 1.3 g (46%) of 1-(o-tolyl)-4-[(4-aminophenyl)methyl]piperazine as an oil.

Provenance & Evidence