Hydrochloric Acid → HCID 21331806, compound

Participants

Reaction Steps

A solution of 4-chloro-7-trifluoromethyl quinoline (1 g, 0.00216 M), 4-(o-tolyl)-1-p-aminobenzylpiperazine (1.3 g, 0.0046 M) and 3 ml of ethanolic hydrogen chloride in 25 ml of ethanol is heated at reflux for 6 hours under nitrogen. The reaction mixture is quenched with ice water, neutralized with aqueous 10% aqueous sodium hydroxide solution and extracted with methylene chloride. The methylene chloride solution is washed with water, dried over anhydrous sodium sulfate and concentrated to a white solid which, after recyrstallization from ethyl acetate/Skellysolve®B, affords 1.9 g (92%) of white crystalline 4-[[4-[[4-(2-methylpenyl)-1-piperazinyl]methyl]phenyl]amino]-7-(trifluoromethyl)quinoline of melting point 208°-210° C.

Provenance & Evidence