4-Chloro-7-(trifluoromethyl)quinoline → HCID 21331846, compound

HRID 1390989Notes

Reaction equation

HRID 1390989 reaction equation
[C:1]1([N:7]2[CH2:12][CH2:11][N:10]([CH2:13][C:14]3[CH:19]=[CH:18][C:17]([NH2:20])=[CH:16][CH:15]=3)[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl[C:22]1[C:31]2[C:26](=[CH:27][C:28]([C:32]([F:35])([F:34])[F:33])=[CH:29][CH:30]=2)[N:25]=[CH:24][CH:23]=1>>[C:1]1([N:7]2[CH2:8][CH2:9][N:10]([CH2:13][C:14]3[CH:15]=[CH:16][C:17]([NH:20][C:22]4[C:31]5[C:26](=[CH:27][C:28]([C:32]([F:35])([F:33])[F:34])=[CH:29][CH:30]=5)[N:25]=[CH:24][CH:23]=4)=[CH:18][CH:19]=3)[CH2:11][CH2:12]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 676684-Chloro-7-(trifluoromethyl)quinolineHCID 23507360HCID 23507360, compound

Product 1

HCID 21331846HCID 21331846, compound

Procedure

In the manner given in Example 1C, 1-phenyl-4-[(4-aminophenyl)methyl]piperazine and 4-chloro-7-(trifluoromethyl)quinoline are reacted together at reflux to give 4-[[4-[[4-phenyl-1-piperazinyl]methyl]phenyl]amino]-7-(trifluoromethyl)quinoline.

Workup

  1. customare reacted together
  2. temperatureat reflux

Sources & evidence

ORD record
ord-d2328381c13341899a19180ac4e1bb34
Source dataset
uspto-grants-1979_02
Patent number
US04140775

Reaction notes

Loading…