HCID 21331891, compound → HCID 21331839, compound

HRID 1390994Notes

Reaction equation

HRID 1390994 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([N:8]2[CH2:13][CH2:12][N:11]([CH2:14][C:15]3[CH:20]=[CH:19][C:18]([N+:21]([O-])=O)=[CH:17][CH:16]=3)[CH2:10][CH2:9]2)[CH:5]=[CH:6][CH:7]=1>[Cl-].[Cl-].[Cl-].[Ti+3]>[F:1][C:2]1[CH:3]=[C:4]([N:8]2[CH2:9][CH2:10][N:11]([CH2:14][C:15]3[CH:16]=[CH:17][C:18]([NH2:21])=[CH:19][CH:20]=3)[CH2:12][CH2:13]2)[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 1

HCID 21331891HCID 21331891, compound

Product 1

HCID 21331839HCID 21331839, compound

Reagents, catalysts & solvents 1

HCID 10313229titanium(III) trichlorideCatalyst

Procedure

In the manner given in Example 1B, 1-(m-fluorophenyl)-4-(p-nitrobenzyl)piperazine is reduced with aqueous titanium trichloride to give 1-(m-fluorophenyl)-4-[(4-aminophenyl)methyl]piperazine.

Sources & evidence

ORD record
ord-65a30e558fca46b1b63d390ff4110fa6
Source dataset
uspto-grants-1979_02
Patent number
US04140775

Reaction notes

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