4-Chloro-7-(trifluoromethyl)quinoline → HCID 21331817, compound

HRID 1391000Notes

Reaction equation

HRID 1391000 reaction equation
[CH2:1]([O:4][C:5]1[CH:6]=[C:7]([N:15]2[CH2:20][CH2:19][N:18]([CH2:21][C:22]3[CH:27]=[CH:26][C:25]([NH2:28])=[CH:24][CH:23]=3)[CH2:17][CH2:16]2)[CH:8]=[C:9]([O:11][CH2:12][CH2:13][CH3:14])[CH:10]=1)[CH2:2][CH3:3].Cl[C:30]1[C:39]2[C:34](=[CH:35][C:36]([C:40]([F:43])([F:42])[F:41])=[CH:37][CH:38]=2)[N:33]=[CH:32][CH:31]=1>>[CH2:1]([O:4][C:5]1[CH:6]=[C:7]([N:15]2[CH2:16][CH2:17][N:18]([CH2:21][C:22]3[CH:27]=[CH:26][C:25]([NH:28][C:30]4[C:39]5[C:34](=[CH:35][C:36]([C:40]([F:43])([F:41])[F:42])=[CH:37][CH:38]=5)[N:33]=[CH:32][CH:31]=4)=[CH:24][CH:23]=3)[CH2:19][CH2:20]2)[CH:8]=[C:9]([O:11][CH2:12][CH2:13][CH3:14])[CH:10]=1)[CH2:2][CH3:3]

Participants

3

Reactant 2

HCID 676684-Chloro-7-(trifluoromethyl)quinolineHCID 21331880HCID 21331880, compound

Product 1

HCID 21331817HCID 21331817, compound

Procedure

In the manner given in Example 1C, 1-(3,5-dipropoxyphenyl)-4-[(4-aminophenyl)methyl]piperazine and 4-chloro-7-(trifluoromethyl)quinoline are reacted together at reflux to give 4-[[4-[[4-(3,5-dipropoxyphenyl)-1-piperazinyl]methyl]phenyl]amino]-7-(trifluoromethyl)quinoline.

Workup

  1. customare reacted together
  2. temperatureat reflux

Sources & evidence

ORD record
ord-8bf55b00f64a4a08a93c94b9239fba32
Source dataset
uspto-grants-1979_02
Patent number
US04140775

Reaction notes

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