4-Chloro-7-(trifluoromethyl)quinoline → HCID 21331889, compound

HRID 1391005Notes

Reaction equation

HRID 1391005 reaction equation
[CH2:1]([C:3]1[C:8]([CH2:9][CH3:10])=[CH:7][CH:6]=[CH:5][C:4]=1[N:11]1[CH2:16][CH2:15][N:14]([CH2:17][C:18]2[CH:23]=[CH:22][C:21]([NH2:24])=[CH:20][CH:19]=2)[CH2:13][CH2:12]1)[CH3:2].Cl[C:26]1[C:35]2[C:30](=[CH:31][C:32]([C:36]([F:39])([F:38])[F:37])=[CH:33][CH:34]=2)[N:29]=[CH:28][CH:27]=1>>[CH2:1]([C:3]1[C:8]([CH2:9][CH3:10])=[CH:7][CH:6]=[CH:5][C:4]=1[N:11]1[CH2:16][CH2:15][N:14]([CH2:17][C:18]2[CH:19]=[CH:20][C:21]([NH:24][C:26]3[C:35]4[C:30](=[CH:31][C:32]([C:36]([F:39])([F:37])[F:38])=[CH:33][CH:34]=4)[N:29]=[CH:28][CH:27]=3)=[CH:22][CH:23]=2)[CH2:13][CH2:12]1)[CH3:2]

Participants

3

Reactant 2

HCID 676684-Chloro-7-(trifluoromethyl)quinolineHCID 21331812HCID 21331812, compound

Product 1

HCID 21331889HCID 21331889, compound

Procedure

In the manner given in Example 1C, 1-(2,3-diethylphenyl)-4-[(4-aminophenyl)methyl]piperazine and 4-chloro-7-(trifluoromethyl)quinoline are reacted together at reflux to give 4-[[4-[[4-(2,3-diethylphenyl)-1-piperazinyl]methyl]phenyl]amino]-7-(trifluoromethyl)quinoline.

Workup

  1. customare reacted together
  2. temperatureat reflux

Sources & evidence

ORD record
ord-a6b8db91e43b449b91138a650f7900b9
Source dataset
uspto-grants-1979_02
Patent number
US04140775

Reaction notes

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