4-Chloro-7-(trifluoromethyl)quinoline → 4-[[4-[[4-(3,5-Dibromophenyl)-1-piperazinyl]methyl]phenyl]amino]-7-(trifluoromethyl)quinoline

HRID 1391013Notes

Reaction equation

HRID 1391013 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([N:9]2[CH2:14][CH2:13][N:12]([CH2:15][C:16]3[CH:21]=[CH:20][C:19]([NH2:22])=[CH:18][CH:17]=3)[CH2:11][CH2:10]2)[CH:5]=[C:6]([Br:8])[CH:7]=1.Cl[C:24]1[C:33]2[C:28](=[CH:29][C:30]([C:34]([F:37])([F:36])[F:35])=[CH:31][CH:32]=2)[N:27]=[CH:26][CH:25]=1>>[Br:1][C:2]1[CH:3]=[C:4]([N:9]2[CH2:14][CH2:13][N:12]([CH2:15][C:16]3[CH:21]=[CH:20][C:19]([NH:22][C:24]4[C:33]5[C:28](=[CH:29][C:30]([C:34]([F:37])([F:35])[F:36])=[CH:31][CH:32]=5)[N:27]=[CH:26][CH:25]=4)=[CH:18][CH:17]=3)[CH2:11][CH2:10]2)[CH:5]=[C:6]([Br:8])[CH:7]=1

Participants

3

Reactant 2

HCID 676684-Chloro-7-(trifluoromethyl)quinolineHCID 21331900HCID 21331900, compound

Product 1

HCID 213318684-[[4-[[4-(3,5-Dibromophenyl)-1-piperazinyl]methyl]phenyl]amino]-7-(trifluoromethyl)quinoline

Procedure

In the manner given in Example 1C, 1-(3,5-dibromophenyl)-4-[(4-aminophenyl)methyl]piperazine and 4-chloro-7-(trifluoromethyl)quinoline are reacted together at reflux to give 4-[[4-[[4-(3,5-dibromophenyl)-1-piperazinyl]methyl]phenyl]amino]-7-(trifluoromethyl)quinoline.

Workup

  1. customare reacted together
  2. temperatureat reflux

Sources & evidence

ORD record
ord-61bc258fcfcb4188be2843e5ca8c95b2
Source dataset
uspto-grants-1979_02
Patent number
US04140775

Reaction notes

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