4-Chloro-7-(trifluoromethyl)quinoline → HCID 21331829, compound

HRID 1391016Notes

Reaction equation

HRID 1391016 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[N:9]1[CH2:14][CH2:13][N:12]([CH2:15][C:16]2[CH:21]=[CH:20][C:19]([NH2:22])=[CH:18][CH:17]=2)[CH2:11][CH2:10]1.Cl[C:24]1[C:33]2[C:28](=[CH:29][C:30]([C:34]([F:37])([F:36])[F:35])=[CH:31][CH:32]=2)[N:27]=[CH:26][CH:25]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[N:9]1[CH2:14][CH2:13][N:12]([CH2:15][C:16]2[CH:21]=[CH:20][C:19]([NH:22][C:24]3[C:33]4[C:28](=[CH:29][C:30]([C:34]([F:37])([F:35])[F:36])=[CH:31][CH:32]=4)[N:27]=[CH:26][CH:25]=3)=[CH:18][CH:17]=2)[CH2:11][CH2:10]1

Participants

3

Reactant 2

HCID 676684-Chloro-7-(trifluoromethyl)quinolineHCID 21331876HCID 21331876, compound

Product 1

HCID 21331829HCID 21331829, compound

Procedure

In the manner given in Example 1C, 1-(2,5-dichlorophenyl)-4-[(4-aminophenyl)methyl]piperazine and 4-chloro-7-(trifluoromethyl)quinoline are reacted together at reflux to give 4-[[4-[[4-(2,5-dichlorophenyl)-1-piperazinyl]methyl]phenyl]amino]-7-(trifluoromethyl)quinoline.

Workup

  1. customare reacted together
  2. temperatureat reflux

Sources & evidence

ORD record
ord-83a4c5490b1a49b498c85f61c334a494
Source dataset
uspto-grants-1979_02
Patent number
US04140775

Reaction notes

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