4-Chloro-7-(trifluoromethyl)quinoline → HCID 21331881, compound

HRID 1391021Notes

Reaction equation

HRID 1391021 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][N:11]([CH:14]([C:16]3[CH:21]=[CH:20][C:19]([NH2:22])=[CH:18][CH:17]=3)[CH3:15])[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.Cl[C:24]1[C:33]2[C:28](=[CH:29][C:30]([C:34]([F:37])([F:36])[F:35])=[CH:31][CH:32]=2)[N:27]=[CH:26][CH:25]=1>>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH2:9][CH2:10][N:11]([CH:14]([C:16]3[CH:17]=[CH:18][C:19]([NH:22][C:24]4[C:33]5[C:28](=[CH:29][C:30]([C:34]([F:37])([F:35])[F:36])=[CH:31][CH:32]=5)[N:27]=[CH:26][CH:25]=4)=[CH:20][CH:21]=3)[CH3:15])[CH2:12][CH2:13]2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 676684-Chloro-7-(trifluoromethyl)quinolineHCID 21331820HCID 21331820, compound

Product 1

HCID 21331881HCID 21331881, compound

Procedure

In the manner given in Example 1C, 1-(4-methylphenyl)-4-[1-(4-aminophenyl)ethyl]piperazine and 4-chloro-7-(trifluoromethyl)quinoline are reacted together at reflux to give 4-[[4-[1-[4-(p-methylphenyl)-1-piperazinyl]ethyl]phenyl]amino]-7-(trifluoromethyl)quinoline.

Workup

  1. customare reacted together
  2. temperatureat reflux

Sources & evidence

ORD record
ord-6db4f871a3474a4bb7d21fde8d2ccd7f
Source dataset
uspto-grants-1979_02
Patent number
US04140775

Reaction notes

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