HCID 21331824, compound → HCID 21331825, compound

HRID 1391022Notes

Reaction equation

HRID 1391022 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][N:11]([CH:14]([C:17]3[CH:22]=[CH:21][C:20]([N+:23]([O-])=O)=[CH:19][CH:18]=3)[CH2:15][CH3:16])[CH2:10][CH2:9]2)=[CH:4][CH:3]=1>[Cl-].[Cl-].[Cl-].[Ti+3]>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH2:9][CH2:10][N:11]([CH:14]([C:17]3[CH:18]=[CH:19][C:20]([NH2:23])=[CH:21][CH:22]=3)[CH2:15][CH3:16])[CH2:12][CH2:13]2)=[CH:6][CH:7]=1

Participants

3

Reactant 1

HCID 21331824HCID 21331824, compound

Product 1

HCID 21331825HCID 21331825, compound

Reagents, catalysts & solvents 1

HCID 10313229titanium(III) trichlorideCatalyst

Procedure

In the manner given in Example 1B, 1-(p-fluorophenyl)-4-[1-(4-nitrophenyl)propyl]piperazine is reduced with aqueous titanium trichloride to give 1-(4-fluorophenyl)-4-[1-(4-aminophenyl)propyl]piperazine.

Sources & evidence

ORD record
ord-cab3f9c279c646208889ab6072f0d81a
Source dataset
uspto-grants-1979_02
Patent number
US04140775

Reaction notes

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