4-Chloro-7-(trifluoromethyl)quinoline → HCID 21331822, compound

HRID 1391023Notes

Reaction equation

HRID 1391023 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][N:11]([CH:14]([C:17]3[CH:22]=[CH:21][C:20]([NH2:23])=[CH:19][CH:18]=3)[CH2:15][CH3:16])[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.Cl[C:25]1[C:34]2[C:29](=[CH:30][C:31]([C:35]([F:38])([F:37])[F:36])=[CH:32][CH:33]=2)[N:28]=[CH:27][CH:26]=1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH2:9][CH2:10][N:11]([CH:14]([C:17]3[CH:18]=[CH:19][C:20]([NH:23][C:25]4[C:34]5[C:29](=[CH:30][C:31]([C:35]([F:38])([F:36])[F:37])=[CH:32][CH:33]=5)[N:28]=[CH:27][CH:26]=4)=[CH:21][CH:22]=3)[CH2:15][CH3:16])[CH2:12][CH2:13]2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 676684-Chloro-7-(trifluoromethyl)quinolineHCID 21331825HCID 21331825, compound

Product 1

HCID 21331822HCID 21331822, compound

Procedure

In the manner given in Example 1C, 1-(p-fluorophenyl)-4-[1-(4-aminophenyl)propyl]piperazine and 4-chloro-7-(trifluoromethyl)quinoline are reacted together at reflux to give 4-[[4-[1-[4-(p-fluorophenyl)-1-piperazinyl]propyl]phenyl]amino]-7-(trifluoromethyl)quinoline.

Workup

  1. customare reacted together
  2. temperatureat reflux

Sources & evidence

ORD record
ord-d88019ca55704fd5810aebdcf7cfb8ba
Source dataset
uspto-grants-1979_02
Patent number
US04140775

Reaction notes

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