2-butyl-1,4-dihydropyrrolo[3,4-b]indol-3(2H)-one → 2-n-Butyl-1,2,3,4-tetrahydropyrrolo[3,4-b]indole

HRID 1391084노트

반응식

HRID 1391084 반응식
[CH2:1]([N:5]1[CH2:16][C:15]2[C:14]3[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=3[NH:8][C:7]=2[C:6]1=O)[CH2:2][CH2:3][CH3:4]>O1CCCC1>[CH2:1]([N:5]1[CH2:16][C:15]2[C:14]3[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=3[NH:8][C:7]=2[CH2:6]1)[CH2:2][CH2:3][CH3:4]

참가 물질

3

반응물 1

HCID 213202522-butyl-1,4-dihydropyrrolo[3,4-b]indol-3(2H)-one

생성물 1

HCID 213202552-n-Butyl-1,2,3,4-tetrahydropyrrolo[3,4-b]indole

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

2-n-Butyl-1,4-dihydropyrrolo[3,4-b]indol-3(2H)-one, 20 g., in dry tetrahydrofuran, 400 ml., is added slowly to a slurry of LiAl H4, 14 g., in tetrahydrofuran, 250 ml. After refluxing twenty hours, the reaction mixture is hydrolyzed with 30 ml. of water, and filtered. After the solvent is removed, one obtains 20.1 g. of a reddish-brown solid. Recrystallization from methanol, 200 ml., gives 11 g. of the title compound, m.p. 151°-2°.

후처리

  1. addition, is added slowly to a slurry of LiAl H4, 14 g
  2. temperatureAfter refluxing twenty hours
  3. filtrationof water, and filtered
  4. customAfter the solvent is removed
  5. customone obtains 20.1 g
  6. customRecrystallization from methanol, 200 ml
  7. custom, gives 11 g

출처 및 근거

ORD 기록
ord-2978e434713f47599bc6bc4fbd789e48
출처 데이터셋
uspto-grants-1979_02
특허 번호
US04140858

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