反应详情

2-n-Butyl-1,4-dihydropyrrolo[3,4-b]indol-3(2H)-one, 20 g., in dry tetrahydrofuran, 400 ml., is added slowly to a slurry of LiAl H4, 14 g., in tetrahydrofuran, 250 ml. After refluxing twenty hours, the reaction mixture is hydrolyzed with 30 ml. of water, and filtered. After the solvent is removed, one obtains 20.1 g. of a reddish-brown solid. Recrystallization from methanol, 200 ml., gives 11 g. of the title compound, m.p. 151°-2°.

1. addition, is added slowly to a slurry of LiAl H4, 14 g
2. temperatureAfter refluxing twenty hours
3. filtrationof water, and filtered
4. customAfter the solvent is removed
5. customone obtains 20.1 g
6. customRecrystallization from methanol, 200 ml
7. custom, gives 11 g