Methyl isothiocyanate → HCID 178486095, compound

HRID 1391209Notes

Reaction equation

HRID 1391209 reaction equation
[NH:1]1[C:9]2[CH2:8][CH2:7][NH:6][CH2:5][C:4]=2[N:3]=[CH:2]1.[CH3:10][N:11]=[C:12]=[S:13]>C(O)C>[CH3:10][NH:11][C:12]([N:6]1[CH2:7][CH2:8][C:9]2[NH:1][CH:2]=[N:3][C:4]=2[CH2:5]1)=[S:13]

Participants

4

Reactant 2

HCID 11167Methyl isothiocyanateHCID 178420865HCID 178420865, compound

Product 1

HCID 178486095HCID 178486095, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 1 g of 4,5,6,7-tetrahydro-imidazo-[4,5-c]-pyridine (Farmaco, Ed. Sci., 1967, 22, 821) and 0.65 g of methyl isothiocyanate in 20 ml of ethanol are refluxed for 8 h. The solution is cooled and filtered: 1.15 g of 5-(N-methyl-thiocarbamoyl)-4,5,6,7-tetrahydro-imidazo-[4,5-c]-pyridine, m.p. 228°, are collected.

Workup

  1. temperatureThe solution is cooled
  2. filtrationfiltered
  3. custom1.15 g of 5-(N-methyl-thiocarbamoyl)-4,5,6,7-tetrahydro-imidazo-[4,5-c]-pyridine, m.p. 228°, are collected

Sources & evidence

ORD record
ord-3474ea188430436cb5fd0b8f418edc63
Source dataset
uspto-grants-1979_02
Patent number
US04141899

Reaction notes

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