Methyl isothiocyanate → HCID 21330728, compound

HRID 1391215Notes

Reaction equation

HRID 1391215 reaction equation
[CH3:1][N:2]1[C:6]2[CH2:7][NH:8][CH2:9][CH2:10][C:5]=2[N:4]=[CH:3]1.[CH3:11][N:12]=[C:13]=[S:14]>C(#N)C>[CH3:1][N:2]1[C:6]2[CH2:7][N:8]([C:13](=[S:14])[NH:12][CH3:11])[CH2:9][CH2:10][C:5]=2[N:4]=[CH:3]1

Participants

4

Reactant 2

HCID 11167Methyl isothiocyanateHCID 21330745HCID 21330745, compound

Product 1

HCID 21330728HCID 21330728, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A solution of 1 g of 3-methyl-4,5,6,7-tetrahydro-imidazo-[4,5-c]-pyridine and 1 g of methyl isothiocyanate in 10 ml of acetonitrile is refluxed for 4 h. The solution is cooled and filtered: 0.9 g of 3-methyl-5-(N-methyl-thiocarbamoyl)-4,5,6,7-tetrahydro-imidazo-[4,5-c]-pyridine, m.p. 235°, are collected.

Workup

  1. temperatureThe solution is cooled
  2. filtrationfiltered
  3. custom0.9 g of 3-methyl-5-(N-methyl-thiocarbamoyl)-4,5,6,7-tetrahydro-imidazo-[4,5-c]-pyridine, m.p. 235°, are collected

Sources & evidence

ORD record
ord-9b5d452d3ea940daa2a9ca6f80b81d87
Source dataset
uspto-grants-1979_02
Patent number
US04141899

Reaction notes

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