Sodium Carbonate → 5-Amino-5-methylheptan-3-one

Participants

Reaction Steps

196.3 g of 2,4,6-triethyl-2,6-dimethyl-1,2,5,6-tetrahydropyrimidine were added dropwise to 300 ml of concentrated hydrochloric acid at 30°-40° C., with stirring. When all of the tetrahydropyrimidine had been added, the entire mixture was stirred for 4-5 hours and then neutralized with sodium carbonate and extracted with benzene. The resulting benzene solution was washed, in turn, with a 5% aqueous solution of sodium carbonate and with water, and was then dried over potassium carbonate. After removing the benzene, the residue was distilled under reduced pressure, giving 72.4 g of 5-amino-5-methyl-3-heptanone (bp 46°-48° C./2.5 mmHg).

Provenance & Evidence