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Bromoacetyl chloride → 1-bromomethyl-8-chloro-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Bromoacetyl chloride | HCID 89602 | — |
| 反応物 | Sodium Acetate | HCID 517045 | — |
| 反応物 | 7-Chloro-2-hydrazinyl-5-phenyl-3H-1,4-benzodiazepine | HCID 12390874 | — |
| 生成物 | 1-bromomethyl-8-chloro-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine | HCID 20205220 | — |
反応手順
In a manner given in Example 1, 7-chloro-5-phenyl-3H-1,4-benzodiazepin-2-yl hydrazine was reacted with bromoacetyl chloride and after 1.5 hours with sodium acetate, then refluxed to give 8-chloro-1-bromomethyl-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04141902 |
| 出典データセット | uspto-grants-1979_02 |
| ORD ID | ord-04b84943a23b4d8786455959bd528d57 |
| 出典メモ | uspto-grants-1979_02 |