2-Chloropropionyl chloride → HCID 21330785, compound

HRID 1391260Notes

Reaction equation

HRID 1391260 reaction equation
[C:1]([C:3]1[C:8]2[C:9]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[Br:22])=[N:10][CH2:11][C:12]([NH:14][NH2:15])=[N:13][C:7]=2[CH:6]=[CH:5][C:4]=1[C:23]#[N:24])#[N:2].[Cl:25][CH:26]([CH3:30])[C:27](Cl)=O.C([O-])(=O)C.[Na+]>>[C:1]([C:3]1[C:8]2[C:9]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[Br:22])=[N:10][CH2:11][C:12]3[N:13]([C:27]([CH:26]([Cl:25])[CH3:30])=[N:15][N:14]=3)[C:7]=2[CH:6]=[CH:5][C:4]=1[C:23]#[N:24])#[N:2]

Participants

4

Reactant 3

HCID 1110192-Chloropropionyl chlorideHCID 517045Sodium AcetateHCID 21330783HCID 21330783, compound

Product 1

HCID 21330785HCID 21330785, compound

Procedure

In the manner given in Example 1, 6,7-dicyano-5-(o-bromophenyl)-3H-1,4-benzodiazepin-2-yl hydrazine was reacted with α-chloropropionyl chloride and after 1.5 hours with sodium acetate, then refluxed to give 7,8-dicyano-1-(α-chloroethyl)-6-(o-bromophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Workup

  1. temperaturerefluxed

Sources & evidence

ORD record
ord-5b789865a5744adbb827584f1e31379d
Source dataset
uspto-grants-1979_02
Patent number
US04141902

Reaction notes

Loading…