Sodium Acetate → HCID 21330775, compound

HRID 1391262Notes

Reaction equation

HRID 1391262 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([CH3:23])[C:5]2[N:11]=[C:10]([NH:12][NH2:13])[CH2:9][N:8]=[C:7]([C:14]3[CH:19]=[CH:18][C:17]([S:20][CH3:21])=[CH:16][CH:15]=3)[C:6]=2[CH:22]=1.[F:24][CH2:25][C:26](Br)=O.C([O-])(=O)C.[Na+]>>[CH3:1][C:2]1[CH:3]=[C:4]([CH3:23])[C:5]2[N:11]3[C:26]([CH2:25][F:24])=[N:13][N:12]=[C:10]3[CH2:9][N:8]=[C:7]([C:14]3[CH:15]=[CH:16][C:17]([S:20][CH3:21])=[CH:18][CH:19]=3)[C:6]=2[CH:22]=1

Participants

4

Reactant 3

HCID 517045Sodium AcetateHCID 20291821HCID 20291821, compoundHCID 23511192HCID 23511192, compound

Product 1

HCID 21330775HCID 21330775, compound

Procedure

In the manner given in Example 1, 7,9-dimethyl-5-[p-(methylthio)phenyl]-3H-1,4-benzodiazepin-2-yl hydrazine was reacted with fluoroacetyl bromide and after 1.5 hours with sodium acetate, then the mixture was refluxed to give 8,10-dimethyl-1-(fluoromethyl)-6-[p-(methylthio)phenyl]-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Workup

  1. temperaturethe mixture was refluxed

Sources & evidence

ORD record
ord-5d3e336389c8464cb134185ab4a24f72
Source dataset
uspto-grants-1979_02
Patent number
US04141902

Reaction notes

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