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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1391266Generated: November 4, 2026

Propyl mercaptan → 8-trifluoromethyl-1-(propylthio)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine

https://huagongshe.com/reaction/1391266

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPropyl mercaptanHCID 7848—
ReactantSodium HydroxideHCID 14798—
Reactant8-(trifluoromethyl)-1-(chloromethyl)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepineHCID 21330780—
Product8-trifluoromethyl-1-(propylthio)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepineHCID 21330779—

Reaction Steps

In the manner given in Example 14, a solution of 8-trifluoromethyl-1-(chloromethyl)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine was heated with propanethiol and sodium hydroxide to give 8-trifluoromethyl-1-(propylthio)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04141902
Source datasetuspto-grants-1979_02
ORD IDord-18b9c47672cb4976924d8e7402988bc7
Source noteuspto-grants-1979_02