Formic Acid → 6-Formamidopyridine-3-carboxamide

Participants

Reaction Conditions

Reaction Steps

6-Aminonicotinamide, 5.6 g, was added to 90% formic acid, 15 ml. After all the crystals were dissolved, the clear solution was heated to 100° C. for 10 minutes. The mixture was cooled and then 4N NaOH was added to adjust the pH to 2.8. The white crystals which formed were separated by filtration and were washed once with cold water followed by acetone wash. The yield of 6-formylaminonicotinamide was 5.6 g. This product had Rf value of 0.53 on thin-layer chromatogram using a solvent system of benzene:methanol, 1:1.

Provenance & Evidence