Phosphoric Acid → 6-Aminonicotinic acid

HRID 1391304Notes

Reaction equation

HRID 1391304 reaction equation
[NH2:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](N)=[O:7])=[CH:4][N:3]=1.P(=O)(O)(O)[OH:12]>>[NH2:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:12])=[O:7])=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 1004Phosphoric AcidHCID 95006-Aminonicotinamide

Product 1

HCID 184966-Aminonicotinic acid

Conditions

Temperature
100 °C

Procedure

6-Aminonicotinamide, 200 g, was dissolved in warm 85% phosphoric acid, 700 ml. The clear solution was heated to 100° C. for 8 hours. The solution was then diluted with 1.5 Kg of ice water. The white crystals thus obtained were separated by filtration, and washed with ice water followed with an acetone wash. The yield of 6-aminonicotinic acid phosphoric salt was 310 g. This product in its phosphoric salt form may be directly incorporated into the therapeutic compositions of the present invention.

Workup

  1. customThe white crystals thus obtained
  2. customwere separated by filtration
  3. washwashed with ice water
  4. washwash

Sources & evidence

ORD record
ord-f842d76580224520965e7be482e44b2f
Source dataset
uspto-grants-1979_02
Patent number
US04141977

Reaction notes

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