HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenol → 8-METHYLQUINAZOLINE-2,4(1H,3H)-DIONE
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenol | HCID 996 | — |
| Reactant | Urea | HCID 1176 | — |
| Reactant | 2-Amino-3-methylbenzoic acid | HCID 78101 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 8-METHYLQUINAZOLINE-2,4(1H,3H)-DIONE | HCID 334023 | 75% |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
3-Methylanthranilic acid (15 g., 0.1 mole), urea (36 g., 0.6 mole) and phenol (86 g.) were mixed together and heated to reflux for three hours. The reaction was then allowed to cool to 100° C. and ethanol (75 ml.) added dropwise. The resulting solid was filtered and washed twice with cold ethanol to afford 13.2 g. (75% yield); m.p. 170° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04141979 |
| Source dataset | uspto-grants-1979_02 |
| ORD ID | ord-104550f892264f24a7d56e5275ddc131 |
| Source note | uspto-grants-1979_02 |