Hydrochloric Acid → HCID 136271466, compound

Participants

Reaction Steps

4'-Chloro-5-ethyl-2-hydroxybenzophenone (65.2 g) and potassium hydroxide (170 g) in water (700 ml) and ethanol (150 ml.) were treated with hydroxylamine hydrochloride (70.0 g), with cooling, and the resulting mixture was stirred for 18 hours at ambient temperature. Dissolution occurred during this time. The solution was acidified with 5N-hydrochloric acid and then extracted with ether (3 × 200 ml.). The combined ether solutions were washed with 10% aqueous sodium carbonate solution (2 × 200 ml.) and evaporated to dryness to give an off-white solid. This solid was recrystallised from 40% benzene/60°-80° C. petrol ether to give a white crystalline solid (29.9 g), second crop (14.5 g) m.p. 117° C.

Provenance & Evidence