3-Ethylphenol → (4-Ethyl-2-hydroxyphenyl)(4-fluorophenyl)methanone

Participants

Reaction Steps

3-Ethylphenol (24.4 g) and 4-fluorobenzoyl chloride (34.9 g) were reacted together as in Example 2 giving three main fractions: B (11.4 g) 126°-129° C. at 0.07 mmHg; C (7.9 g), 129°-132° C. at 0.06 mmHg; D (5.9 g), 132°-150° C. at 0.06 mmHg, all containing ~ 80% of the required isomer. B (4.0 g) was separated by preparative thin layer chromatography to give the title compound (2.6 g), m.p. 44°-48° C. The same compound was obtained using the method of Example 4.

Provenance & Evidence