HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Ethylphenol → (4-Ethyl-2-hydroxyphenyl)(3-fluorophenyl)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Ethylphenol | HCID 12101 | — |
| Reactant | 3-Fluorobenzoyl chloride | HCID 74376 | — |
| Reactant | Aluminum(III) Chloride | HCID 6451240 | — |
| Solvent | 1,1,2,2-Tetrachloroethane | HCID 6591 | — |
| Product | (4-Ethyl-2-hydroxyphenyl)(3-fluorophenyl)methanone | HCID 13838750 | — |
Reaction Conditions
| Temperature | 105 °C |
|---|
Reaction Steps
This compound was prepared from 3-ethylphenol (12.2 g), 3-fluorobenzoyl chloride (17.5 g) and aluminium chloride (26.7 g) in 1,1,2,2-tetrachloroethane (75 ml) using the same conditions as in Example 2, but heating under reflux, not at 105° C. The product was purified by chromatography on a silica column m.p. between 0° and 20° C. ηo22 1.5962. The same product was obtained using the method of Example 4.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04141995 |
| Source dataset | uspto-grants-1979_02 |
| ORD ID | ord-52b8e87add01409395cee6482e7eb0ae |
| Source note | uspto-grants-1979_02 |