Potassium Permanganate → 5-Acetyl-1-methyl-benzimidazole-2-carboxylic acid

HRID 1391344Notes

Reaction equation

[C:1]([C:4]1[CH:15]=[CH:14][C:7]2[N:8]([CH3:13])[C:9]([CH2:11][OH:12])=[N:10][C:6]=2[CH:5]=1)(=[O:3])[CH3:2].[Mn]([O-])(=O)(=O)=[O:17].[K+]>>[C:1]([C:4]1[CH:15]=[CH:14][C:7]2[N:8]([CH3:13])[C:9]([C:11]([OH:17])=[O:12])=[N:10][C:6]=2[CH:5]=1)(=[O:3])[CH3:2]

Participants

Reactant 2

HCID 516875Potassium Permanganate

HCID 130606775-Acetyl-1-methyl-1H-benzimidazole-2-methanol

Product 1

HCID 128066545-Acetyl-1-methyl-benzimidazole-2-carboxylic acid

Procedure

In a manner analogous to that described in Example 12, 4.1 g of 5-acetyl-1-methyl-benzimidazole-2-methanol can be oxidised with 4 g of potassium permanganate to give 5-acetyl-1-methyl-benzimidazole-2-carboxylic acid with a melting point above 135°.

Sources & evidence

ORD record: ord-bd84c8b39604480ebc983a667fc3d8a4
Source dataset: uspto-grants-1979_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04141982

Reaction notes

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