Ethanol → HCID 178525838, compound

HRID 1391366Notes

Reaction equation

HRID 1391366 reaction equation
C([CH2:6][NH:7][NH:8][C:9]([NH:11][CH:12]=O)=[S:10])(OCC)=O.[OH-:14].[K+].S(=O)(=O)(O)O.[CH2:21]([OH:23])C>>[C:21]([CH2:12][N:11]1[CH:6]=[N:7][N:8]=[C:9]1[SH:10])([OH:23])=[O:14]

Participants

5

Reactant 4

HCID 702EthanolHCID 1118Sulfuric AcidHCID 14797Potassium HydroxideHCID 21331183HCID 21331183, compound

Product 1

HCID 178525838HCID 178525838, compound

Procedure

1-Carbethoxymethyl-4-formylthiosemicarbazide (0.50 g., 2.44 mmol.) was dissolved in 5 ml. of ethanol and 5 ml. (2 equivalents) of aqueous potassium hydroxide solution was added. The reaction mixture was refluxed for five hours then cooled, acidified to pH 2.0 with 6N sulfuric acid and evaporated to dryness. The residue was extracted with acetone to give 4-carboxymethyl-1,2,4-triazole-3-thiol.

Workup

  1. temperatureThe reaction mixture was refluxed for five hours
  2. temperaturethen cooled
  3. customevaporated to dryness
  4. extractionThe residue was extracted with acetone

Sources & evidence

ORD record
ord-70a24d5fdf404fbb87395dd6119e06c6
Source dataset
uspto-grants-1979_02
Patent number
US04142046

Reaction notes

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