Tetrafluoro-m-phenylenediamine dihydrochloride → HCID 69199907, compound

HRID 1391394Notes

Reaction equation

HRID 1391394 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([CH2:8][CH2:9][CH2:10][NH:11][C:12]2[CH:17]=[CH:16][C:15]([N+:18]([O-])=O)=[CH:14][CH:13]=2)[CH2:4][CH2:3]1.C1(N)C(F)=C(F)C(F)=C(N)C=1F.[ClH:33].Cl>[Zn].[Cl-].[NH4+].O.C(O)C>[ClH:33].[ClH:33].[CH3:1][N:2]1[CH2:3][CH2:4][N:5]([CH2:8][CH2:9][CH2:10][NH:11][C:12]2[CH:13]=[CH:14][C:15]([NH2:18])=[CH:16][CH:17]=2)[CH2:6][CH2:7]1

Participants

4

Reactant 2

HCID 149026Tetrafluoro-m-phenylenediamine dihydrochlorideHCID 21975010N-[3-(4-methylpiperazin-1-yl)propyl]-4-nitro-1-aminobenzene

Product 1

HCID 69199907HCID 69199907, compound

Reagents, catalysts & solvents 1

HCID 131726756ZINC ammonium chloride water ethanolCatalyst

Procedure

The N-[3-(4-methyl-piperazin-1-yl)propyl]-4-nitro-1-aminobenzene (9) obtained above was reduced with a boiling zinc/ammonium chloride/water/ethanol mixture. The corresponding amine was isolated in dihydrochloride form.

Sources & evidence

ORD record
ord-3fcd908067354b06a734348b64fe4194
Source dataset
uspto-grants-2008_03
Patent number
US07338536B2

Reaction notes

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